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Oral cavity squamous cell carcinoma

MedGen UID:
108436
Concept ID:
C0585362
Neoplastic Process
Synonyms: Oral Cavity Squamous Cell Carcinoma; Oral Squamous Cell Carcinoma; Oral Squamous Cell Carcinomas; Squamous Cell Carcinoma of the Mouth
SNOMED CT: Squamous cell carcinoma of mouth (307502000)
 
Monarch Initiative: MONDO:0004958
Orphanet: ORPHA502363

Definition

A rare head and neck tumor characterized by a firm infiltrative neoplasm with squamous differentiation, arising from the mucosal epithelium, and most commonly located in the tongue, floor of the mouth, or gingiva, but also the buccal mucosa or any other area of the oral cavity, depending on prevailing risk factors (such as smoking, alcohol consumption, and tobacco chewing). Patients present with a variably white, erythematous, mixed, nodular, or ulcerated lesion, which may cause discomfort, pain, or reduced mobility of the tongue. The tumor is aggressive with a propensity for local invasion and early lymph node metastasis. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOral cavity squamous cell carcinoma

Professional guidelines

PubMed

Mohamad I, Glaun MDE, Prabhash K, Busheri A, Lai SY, Noronha V, Hosni A
Am Soc Clin Oncol Educ Book 2023 May;43:e389810. doi: 10.1200/EDBK_389810. PMID: 37200591
Thompson LDR, Fitzpatrick SG, Müller S, Eisenberg E, Upadhyaya JD, Lingen MW, Vigneswaran N, Woo SB, Bhattacharyya I, Bilodeau EA, Carlos R, Islam MN, Leon ME, Lewis JS Jr, Magliocca KR, Mani H, Mehrad M, Purgina B, Richardson M, Wenig BM, Cohen DM
Head Neck Pathol 2021 Jun;15(2):572-587. Epub 2021 Jan 7 doi: 10.1007/s12105-020-01262-9. PMID: 33415517Free PMC Article
Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche' F, Nicolai P, O'Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C
Radiother Oncol 2018 Jan;126(1):3-24. Epub 2017 Nov 24 doi: 10.1016/j.radonc.2017.10.016. PMID: 29180076

Recent clinical studies

Etiology

Katirachi SK, Grønlund MP, Jakobsen KK, Grønhøj C, von Buchwald C
Viruses 2023 Feb 6;15(2) doi: 10.3390/v15020451. PMID: 36851665Free PMC Article
Chamoli A, Gosavi AS, Shirwadkar UP, Wangdale KV, Behera SK, Kurrey NK, Kalia K, Mandoli A
Oral Oncol 2021 Oct;121:105451. Epub 2021 Jul 28 doi: 10.1016/j.oraloncology.2021.105451. PMID: 34329869
Howard A, Agrawal N, Gooi Z
Hematol Oncol Clin North Am 2021 Oct;35(5):895-911. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.003. PMID: 34274176
Thompson LDR, Fitzpatrick SG, Müller S, Eisenberg E, Upadhyaya JD, Lingen MW, Vigneswaran N, Woo SB, Bhattacharyya I, Bilodeau EA, Carlos R, Islam MN, Leon ME, Lewis JS Jr, Magliocca KR, Mani H, Mehrad M, Purgina B, Richardson M, Wenig BM, Cohen DM
Head Neck Pathol 2021 Jun;15(2):572-587. Epub 2021 Jan 7 doi: 10.1007/s12105-020-01262-9. PMID: 33415517Free PMC Article
Ettinger KS, Ganry L, Fernandes RP
Oral Maxillofac Surg Clin North Am 2019 Feb;31(1):13-29. Epub 2018 Oct 25 doi: 10.1016/j.coms.2018.08.002. PMID: 30454788

Diagnosis

Rich BJ, Samuels SE, Azzam GA, Kubicek G, Freedman L
Crit Rev Oncog 2024;29(3):5-24. doi: 10.1615/CritRevOncog.2023050055. PMID: 38683151
Chamoli A, Gosavi AS, Shirwadkar UP, Wangdale KV, Behera SK, Kurrey NK, Kalia K, Mandoli A
Oral Oncol 2021 Oct;121:105451. Epub 2021 Jul 28 doi: 10.1016/j.oraloncology.2021.105451. PMID: 34329869
Howard A, Agrawal N, Gooi Z
Hematol Oncol Clin North Am 2021 Oct;35(5):895-911. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.003. PMID: 34274176
Thompson LDR, Fitzpatrick SG, Müller S, Eisenberg E, Upadhyaya JD, Lingen MW, Vigneswaran N, Woo SB, Bhattacharyya I, Bilodeau EA, Carlos R, Islam MN, Leon ME, Lewis JS Jr, Magliocca KR, Mani H, Mehrad M, Purgina B, Richardson M, Wenig BM, Cohen DM
Head Neck Pathol 2021 Jun;15(2):572-587. Epub 2021 Jan 7 doi: 10.1007/s12105-020-01262-9. PMID: 33415517Free PMC Article
Ettinger KS, Yetzer JG
Oral Maxillofac Surg Clin North Am 2017 Nov;29(4):487-501. doi: 10.1016/j.coms.2017.07.004. PMID: 28987229

Therapy

Liu S, Knochelmann HM, Lomeli SH, Hong A, Richardson M, Yang Z, Lim RJ, Wang Y, Dumitras C, Krysan K, Timmers C, Romeo MJ, Krieg C, O'Quinn EC, Horton JD, Dubinett SM, Paulos CM, Neskey DM, Lo RS
Cell Rep Med 2021 Oct 19;2(10):100411. doi: 10.1016/j.xcrm.2021.100411. PMID: 34755131Free PMC Article
Abdelmeguid AS, Silver NL, Boonsripitayanon M, Glisson BS, Ferrarotto R, Gunn GB, Phan J, Gillenwater AM, Hanna EY
Cancer 2021 Sep 1;127(17):3107-3112. Epub 2021 Apr 28 doi: 10.1002/cncr.33616. PMID: 33909292
Chang J, Sunwoo JB, Shah JL, Hara W, Hong J, Colevas AD, Divi V
Otolaryngol Head Neck Surg 2021 May;164(5):1044-1051. Epub 2020 Sep 22 doi: 10.1177/0194599820960146. PMID: 32957854
Schoenfeld JD, Hanna GJ, Jo VY, Rawal B, Chen YH, Catalano PS, Lako A, Ciantra Z, Weirather JL, Criscitiello S, Luoma A, Chau N, Lorch J, Kass JI, Annino D, Goguen L, Desai A, Ross B, Shah HJ, Jacene HA, Margalit DN, Tishler RB, Wucherpfennig KW, Rodig SJ, Uppaluri R, Haddad RI
JAMA Oncol 2020 Oct 1;6(10):1563-1570. doi: 10.1001/jamaoncol.2020.2955. PMID: 32852531Free PMC Article
Mastronikolis NS, Tsiambas E, Papadas TA, Fotiades PP, Papadas AT, Mastronikolis SN, Kastanioudakis I, Ragos V
J BUON 2017 May-Jun;22(3):610-613. PMID: 28730764

Prognosis

Rich BJ, Samuels SE, Azzam GA, Kubicek G, Freedman L
Crit Rev Oncog 2024;29(3):5-24. doi: 10.1615/CritRevOncog.2023050055. PMID: 38683151
Lan T, Ren S, Hu H, Wang R, Chen Q, Wu F, Xu Q, Li Y, Shao L, Wang L, Liu X, Cao H, Li J
Recent Pat Anticancer Drug Discov 2024;19(3):354-372. doi: 10.2174/1574892818666230602112042. PMID: 38214321
Contrera KJ, Zafereo ME, Yaniv D, Roberts DB, Gillenwater AM, Hanna EY, Weber RS, Myers JN, Chang EI, Garvey PB, Hanasono MM, Yu P, Hutcheson KA, Fuller CD, Tyler MA, Neskey DM
Oral Oncol 2022 Nov;134:106127. Epub 2022 Sep 23 doi: 10.1016/j.oraloncology.2022.106127. PMID: 36155359
Ko CA, Fang KH, Hsu CM, Lee YC, Chang GH, Huang EI, Tsai MS, Tsai YT
Head Neck 2021 Sep;43(9):2740-2754. Epub 2021 May 14 doi: 10.1002/hed.26738. PMID: 33991004
Chi AC, Day TA, Neville BW
CA Cancer J Clin 2015 Sep-Oct;65(5):401-21. Epub 2015 Jul 27 doi: 10.3322/caac.21293. PMID: 26215712

Clinical prediction guides

Liu S, Knochelmann HM, Lomeli SH, Hong A, Richardson M, Yang Z, Lim RJ, Wang Y, Dumitras C, Krysan K, Timmers C, Romeo MJ, Krieg C, O'Quinn EC, Horton JD, Dubinett SM, Paulos CM, Neskey DM, Lo RS
Cell Rep Med 2021 Oct 19;2(10):100411. doi: 10.1016/j.xcrm.2021.100411. PMID: 34755131Free PMC Article
Thompson LDR, Fitzpatrick SG, Müller S, Eisenberg E, Upadhyaya JD, Lingen MW, Vigneswaran N, Woo SB, Bhattacharyya I, Bilodeau EA, Carlos R, Islam MN, Leon ME, Lewis JS Jr, Magliocca KR, Mani H, Mehrad M, Purgina B, Richardson M, Wenig BM, Cohen DM
Head Neck Pathol 2021 Jun;15(2):572-587. Epub 2021 Jan 7 doi: 10.1007/s12105-020-01262-9. PMID: 33415517Free PMC Article
Schoenfeld JD, Hanna GJ, Jo VY, Rawal B, Chen YH, Catalano PS, Lako A, Ciantra Z, Weirather JL, Criscitiello S, Luoma A, Chau N, Lorch J, Kass JI, Annino D, Goguen L, Desai A, Ross B, Shah HJ, Jacene HA, Margalit DN, Tishler RB, Wucherpfennig KW, Rodig SJ, Uppaluri R, Haddad RI
JAMA Oncol 2020 Oct 1;6(10):1563-1570. doi: 10.1001/jamaoncol.2020.2955. PMID: 32852531Free PMC Article
Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche' F, Nicolai P, O'Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C
Radiother Oncol 2018 Jan;126(1):3-24. Epub 2017 Nov 24 doi: 10.1016/j.radonc.2017.10.016. PMID: 29180076
Bewley AF, Farwell DG
Clin Dermatol 2017 Sep-Oct;35(5):461-467. Epub 2017 Jun 27 doi: 10.1016/j.clindermatol.2017.06.008. PMID: 28916027

Recent systematic reviews

Iocca O, Copelli C, Garzino-Demo P, Ramieri G, Rubattino S, Sedran L, Volpe F, Manfuso A, Longo F, Sanchez-Aniceto G, Rivero-Calle Á, García-Sánchez A, Pellini R, Petruzzi G, Moretto S, Al-Qamachi L, Aga H, Ridley S, Di Maio P
Eur Arch Otorhinolaryngol 2023 Sep;280(9):4205-4214. Epub 2023 Jun 6 doi: 10.1007/s00405-023-08007-8. PMID: 37280380Free PMC Article
Lee MK, Choi Y
Oral Oncol 2023 Jan;136:106249. Epub 2022 Nov 20 doi: 10.1016/j.oraloncology.2022.106249. PMID: 36417807
Kang YJ, Kang MJ, Ahn HS, Hwang SH
J Laryngol Otol 2023 Jun;137(6):599-607. Epub 2022 Sep 12 doi: 10.1017/S0022215122002043. PMID: 36089746
Christianto S, Li KY, Huang TH, Su YX
Laryngoscope 2022 Sep;132(9):1760-1770. Epub 2021 Dec 25 doi: 10.1002/lary.29996. PMID: 34953144
Kaminagakura E, Tango RN, Cruz-Perez D, Bonan R, Yamamoto de Almeida L, de Almeida Lança ML, Bonan P, Martins H, Takahama A Jr, Ito FA, Coutinho-Camillo CM, Lourenço SV, Caneppele T, Sikora AG, Kowalski LP, Young S
Head Neck 2022 Feb;44(2):548-561. Epub 2021 Nov 22 doi: 10.1002/hed.26940. PMID: 34808012

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